Micro-USG (MUS) ExactVu™ w diagnostyce CaP

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Tańsze, bardziej dostępne badane obrazowe prostaty - przyszla konkurencja dla mpMRI?


ExactVu™ - the world's first 29 MHz micro-ultrasound system - Exact Imaging
https://www.exactimaging.com/



PRI-MUS™ Risk Identification Protocol - Exact Imaging
https://www.exactimaging.com/primus-protocol



Micro-Ultrasound: a way to bring imaging for prostate cancer back to urology
(...)
The first multicenter prospective analysis of 1040 patients found a sensitivity and NPV (negative predictive value)for PC of
Gleason grade group ≥2 of mpMRI vs. MUS of 90% vs. 94% (p = 0.03) and 77% vs. 85%, respectively [36].
The NPV of mpMRI and MUS for Gleason group ≥3 of 93% is comparable with the 88% found in the PROMIS trial for Gleason grade group ≥3 or cancer core length ≥6 mm.
The biopsy protocol differed somewhat between the participating sites reducing the quality of the data. In summary, these studies form a sufficient basis for further prospective evaluation of MUSGB as an alternative or addition to MRIGB.
The fact that some lesions are undetectable by mpMRI but clearly visible on MUS is supported by our own finding (Fig. 3). More studies are urgently needed to find a clear place for MUS in the field of PC detection.
https://www.sciencedirect.com/science/a ... 8221000015



Micro-Ultrasound for Easier Prostate Cancer Screening

According to an article published in the Canadian Urological Association Journal, micro-ultrasound is more sensitive to these types of cancers, functioning as a single-session option for prostate screening and targeted biopsy.

“High-resolution micro-ultrasound has the capability of imaging prostate cancer based on detecting alterations in ductal anatomy, analogous to multiparametric magnetic resonance imaging (mpMRI),” said lead study author Laurence Klotz, M.D., chair of prostate cancer research at Sunnybrook Hospital in Toronto, Canada. “This technology has the potential advantages of relatively low cost, simplicity, and accessibility compared to mpMRI.”

In this study, the team evaluated images from 1,040 men from 11 sites in seven countries who previously underwent mpMRI and also micro-ultrasound-guided biopsy. These biopsies were captured from both mpMRI targets with a PI-RADS score of >3 and micro-ultrasound targets with a PRIMUS >3.

According to their analysis, 39.5 percent of men were diagnosed with clinically significant prostate cancer, meaning they had a Gleason grade group of greater than or equal to 2. For micro-ultrasound and mpMRI, sensitivity was 94 percent and 90 percent, respectively, and their negative predictive value was 85 percent and 77 percent, respectively. Both strategies had 22-percent specificity, and their positive predictive values were similar – 44 percent and 43 percent, respectively.

Given the higher sensitivity for clinically significant prostate cancer compared to mpMRI and its lower cost and single-session option for prostate screening and targeted biopsy, micro-ultrasound could be an attractive imaging strategy for some patients.

https://www.diagnosticimaging.com/view/ ... -screening