APCCC 2017 Management of Patients with Advanced PCa (ang.)

APCCC 2017 Management of Patients with Advanced PCa (ang.)

Nieprzeczytany postautor: zosia bluszcz » 12 lis 2017, 02:00

Bardzo interesująca lektura.
Rownie interesujący jest brak obecnosci na tej bardzo waznej konferencji ktoregokolwiek z luminarzy polskiej urologii...


Management of Patients with Advanced Prostate Cancer:
The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017



Abstract

Background:
In advanced prostate cancer (APC), successful drug development as well as advances in imaging and molecular characterisation have resulted in multiple areas where there is lack of evidence or low level of evidence. The Advanced Prostate Cancer Consensus Conference (APCCC) 2017 addressed some of these topics.

Objective:
To present the report of APCCC 2017.

Design, setting, and participants:

Ten important areas of controversy in APC management were identified:
1. Management of high-risk localised and locally advanced prostate cancer
2. "Oligometastatic" prostate cancer
3. Management of castration-sensitive/naive prostate cancer (CNCP)
4. Management of castration-resistant prostate cancer (CRPC)
5. Imaging in APC
6. Use of osteoclast-targeted therapy for skeletal related events (SRE)/symptomatic skeletal events (SSE) prevention for metastatic CRPC (mCRPC; not for osteoporosis/bone loss)
7. Molecular characterisation
8. Genetic counselling/testing
9. Side effects of systemic treatment: prevention, management, and supportive care
10. Global access to prostate cancer drugs and treatment in countries with limited resources

A panel of 60 international prostate cancer experts developed the program and the consensus questions.

Outcome measurements and statistical analysis:

The panel voted publicly but anonymously on 150 predefined questions, which have been developed following a modified Delphi process.

Results and limitations:

Voting is based on panellist opinion, and thus is not based on a standard literature review or meta-analysis. The outcomes of the voting had varying degrees of support, as reflected in the wording of this article, as well as in the detailed voting results recorded in Supplementary data.

Conclusions:
The presented expert voting results can be used for support in areas of management of men with APC where there is no high-level evidence, but individualised treatment decisions should as always be based on all of the data available, including disease extent and location, prior therapies regardless of type, host factors including comorbidities, as well as patient preferences, current and emerging evidence, and logistical and economic constraints. Inclusion of men with APC in clinical trials should be strongly encouraged.
Importantly, APCCC 2017 again identified important areas in need of trials specifically designed to address them.

Patient summary:
The second Advanced Prostate Cancer Consensus Conference APCCC 2017 did provide a forum for discussion and debates on current treatment options for men with advanced prostate cancer.
The aim of the conference is to bring the expertise of world experts to care givers around the world who see less patients with prostate cancer.
The conference concluded with a discussion and voting of the expert panel on predefined consensus questions, targeting areas of primary clinical relevance. The results of these expert opinion votes are embedded in the clinical context of current treatment of men with advanced prostate cancer and provide a practical guide to clinicians to assist in the discussions with men with prostate cancer as part of a shared and multidisciplinary decision-making process.

# 2017 European Association of Urology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc- nd/4.0/).





Management of Patients with Advanced Prostate Cancer- The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.pdf
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